Switzerland has set ambitious efficiency targets to help it meet its 2050 energy goals. The objective of the report is to investigate if these could be endangered by potential efficiency losses due to the implementation of flexible demand-side management (DSM). E4tech reviewed commercial and industrial DSM potential in Switzerland and applied a multi-criteria ranking to identify representative examples for detailed case studies. We then interviewed industry experts and analysed operation patterns for three applications: cement mills, deep-freeze warehouses, and waste-water treatment plants, looking at the expected impacts on efficiency. The final report contains application-specific recommendations and an informed discussion of the trade-offs between demand-side management and energy efficiency, to help the client in tailoring its funding policy.